Applies only to oral form of both agents. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Do not double the dose to catch up. Corrected Calcium. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Use Caution/Monitor. Most The dosage of Venofer is expressed in mg of elemental iron. Separate dosing of tetracyclines from these products. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Found in multiple references. 4. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Avoid or Use Alternate Drug. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. A healthcare provider will give you this injection. May increase risk of hypotension. Separate by 2 hr. Use Caution/Monitor. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Your doctor will do laboratory tests to monitor your response. 3. Administer a test INFeD dose prior to the first therapeutic dose. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Venofer must only be administered intravenously either by slow injection or by infusion. Minor (1)iron sucrose, captopril. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Human studies not conducted. 5. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Reactions have occurred following the first dose or subsequent doses of Venofer. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). Do not administer Venofer to patients with iron overload. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Steps on how to print your input & results: 1. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. I. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. The above information is provided for general Use Caution/Monitor. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Applies only to oral form of both agents. Applies only to oral form of both agents. prescription products. This topic . iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Minor/Significance Unknown. In the text below the tool there is more information on how the iron deficit is calculated. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Copyright 1993-2021 Med J Aust. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Use Caution/Monitor. commonly, these are "preferred" (on formulary) brand drugs. Applies only to oral form of both agents. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Applies only to oral form of both agents. Most Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. commonly, these are generic drugs. Applies only to oral form of both agents. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Monitor for signs and symptoms of hypotension following each administration of Venofer. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. [. Use Caution/Monitor. You can further save the PDF or print it. It can be expressed in mg per ml. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Use Caution/Monitor. Fatal reactions have also occurred in situations where the test dose was tolerated. If either is present, do not use the liquid. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Avoid or Use Alternate Drug. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Applies only to oral form of both agents. Do Not Copy, Distribute or otherwise Disseminate without express permission. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Use alternatives if available. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Do Not Copy, Distribute or otherwise Disseminate without express permission. Copyright(c) 2023 First Databank, Inc. Included in the iron dextran package insert. Intravenous iron-dextran: therapeutic and experimental possibilities. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Nutrition. Applies only to oral form of both agents. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Properly discard this product when it is expired or no longer needed. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. The iron formulation choice remains for the clinician to make. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Your doctor will do laboratory tests to monitor your response. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to https://www.uptodate.com/ (Requires subscription). Minor/Significance Unknown. Avoid or Use Alternate Drug. Schweiz Med Wochenschr; 100(7):301-3. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Anemia; 2015: 763576. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Many patients with kidney disease cannot get enough iron from food and require injections. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. 2000 Jan;22(1):39-43. Use Caution/Monitor. No data are available regarding overdosage of Venofer in humans. Modify Therapy/Monitor Closely. Venofer may reduce the absorption of concomitantly administered oral iron preparations. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Administer Venofer early during the dialysis session (generally within the first hour). May increase risk of hypotension. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Minor/Significance Unknown. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. 2015: 763576. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Separate dosing of tetracyclines from these products. Either decreases levels of the other by inhibition of GI absorption. Baloxavir may bind to polyvalent cations resulting in decreased absorption. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Nutr Clin Pract. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. STORAGE: Consult the product instructions and your pharmacist for storage details. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). David McAuley, Pharm.D. Always ask your health care professional for complete information about this product and your specific health needs. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Access your plan list on any device mobile or desktop. Use Caution/Monitor. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. US residents can call their local poison control center at 1-800-222-1222. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Burns DL, Mascioli EA, Bistrian BR. Applies only to oral form of both agents. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 10th ed. Minor/Significance Unknown. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. 1 Dosing for patients who weigh less than 50 kg Applies only to oral form of both agents. Modify Therapy/Monitor Closely. This drug is available at a middle level co-pay. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Parenteral iron supplementation. Drug class: Iron products. Minor/Significance Unknown. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. ONE DOSE. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. This site complies with the HONcode standard for trust- worthy health information: verify here. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Applies only to oral form of both agents. Information last revised December 2022. 2010;18(3). OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Applies only to oral form of both agents. Accessed: 4/12/2011. Venofer treatment may be repeated if necessary. Minor/Significance Unknown. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Applies only to oral form of both agents. Available for Android and iOS devices. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. MISSED DOSE: It is important to get each dose of this medication as scheduled. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Ferric gluconate: 12.5 mg/mL. Use Caution/Monitor. Pain, swelling, or redness at the injection site may occur. Applies only to oral form of both agents. official version of the modified score here. The primary endpoint was the proportion of patients with . Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Use Caution/Monitor. DICP. Avoid or Use Alternate Drug. Schweiz Med Wochenschr; 100(7):301-3. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of manganese by inhibition of GI absorption. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Applies only to oral form of both agents. Minor (1)iron sucrose, benazepril. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Corrected Sodium and Effective Osmolality. Dose. Canada residents can call a provincial poison control center. Use Caution/Monitor. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] This site complies with the HONcode standard for trust- worthy health information: verify here. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Pregnancy: Risk Summary-Clinical Considerations. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Kidney Int. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Applies only to oral form of both agents. Step 2: Calculation and administration of the maximum individual iron dose(s): . Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Feraheme does not contain antimicrobial preservatives. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Applies only to oral form of both agents. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. The dosage of Venofer is expressed in mg of elemental iron. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of .