can collagen peptides cause migraines can collagen peptides cause migraines

View abstract. As mentioned, collagen is a large protein that contains many different peptides and amino acids. 2022 Sep 2;23(1):113. doi: 10.1186/s10194-022-01478-w. Medicine (Baltimore). Chemical additives in collagen peptide supplements, such as anti-caking substances and preservatives are common causes of acne flare-ups in those who notice increased breakouts with collagen use. Moskowitz RW. Collagen loss with age can cause increased tooth sensitivity and decreased tooth strength. Although rare and typically mild, side effects of collagen peptides on skin often take the form of inflammation and skin breakouts or rashes. We avoid using tertiary references. Maximal isometric voluntary contractions, countermovement jumps (CMJ), muscle soreness (200 mm visual analogue scale), pressure pain threshold, Brief Assessment of Mood Adapted (BAM +) and a range of blood markers associated with muscle damage, inflammation and bone turnover C-terminal telopeptide of type 1 collagen (-CTX) and N-terminal propeptides of type 1 pro-collagen (P1NP) were measured before supplementation (baseline; BL), pre, post, 1.5, 24 and 48 h post-exercise. Lopez HL, Ziegenfuss TN, Park J. 2011;35(3):341-8. J Med Food. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Its important, in such cases, not to over-consume collagen peptides or take them right before sleeping. This means that the manufacturer has broken the collagen in the supplements down into peptides, making it easier for the body to absorb and use. View abstract. Clipboard, Search History, and several other advanced features are temporarily unavailable. In the cosmetic industry, marine collagen is one of the most popular types, as it causes less inflammation than animal sources and is less likely to contain Bauza E, Oberto G, Berghi A, Dal CF, Domloge N. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. Please enable it to take advantage of the complete set of features! Clin Exp Dermatol. Can diet help improve depression symptoms? Unable to load your collection due to an error, Unable to load your delegates due to an error. G0701603/MRC_/Medical Research Council/United Kingdom, MR/P020941/1/MRC_/Medical Research Council/United Kingdom. Collagen peptide supplements usually come in the form of either powders or pills and are generally considered equally safe and effective for skin care purposes. View abstract. View abstract. Zdzieblik D, Oesser S, Gollhofer A, Knig D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. J Dermatolog Treat. Undergoing the hydrolyzation process makes collagen easier for the body to absorb. For example, in a study in the Journal of Medical Nutrition and Nutraceuticals, several women drank a mixture containing various vitamins, minerals, hydrolyzed collagen, and hyaluronic acid. Read on to learn more about L-tryptophan, including its safety and efficacy. ProT Powder Collagen Protein - 32 Servings. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. 2000;30(2):87-99. View abstract. Learn about some top options here. If you experience any adverse reactions after taking collagen, stop taking it and speak to your An official website of the United States government. Therapeutic role of melatonin in migraine prophylaxis: A systematic review. Oral collagen supplementation for skin aging: A fad or the future? The following are the most common types of collagen a person can find in stores or online: Most supplements will contain several of these, and possibly other, types of collagen. Many believe that collagen supplements can help reduce the effects of aging, such as by adding moisture to the skin, reducing wrinkles, and improving elasticity. 8600 Rockville Pike 2018 Mar;78(4):411-437. doi: 10.1007/s40265-018-0865-y. Also of note, too much copper intake can make you nauseous and give you gastrointestinal issues. sharing sensitive information, make sure youre on a federal Collagen peptides powder may also cause headaches, dizziness, or lightheadedness in some users. Although certain foods, such as bone broth, contain collagen, people who want wrinkle-free skin or other health benefits often look to supplements to increase their collagen intake. However, it is important to understand what collagen and biotin are and what research is available to support these claims. Although rare and typically mild, side effects of collagen peptides on skin often take the form of inflammation and skin breakouts or rashes. Certain foods contain nutrients that are necessary for collagen production. Collagen supplements have the potential to cause both headaches and migraines. Mar Drugs. 8600 Rockville Pike The less your body has to work to break down the collagen when you consume it, the less likely you are to get a stomach ache or other unwanted side effects. Insulin is an example of a peptide drug, which is composed of 51 amino acids. pii: E1356. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. Siahaan EA, Agusman, Pangestuti R, Shin KH, Kim SK. View abstract. 2012;60(16):4096-4101. and transmitted securely. In rare cases, a peptide allergy can occur. In particular, the spongy cartilage of the joints starts to wear away. Expert Opin Investig Drugs. What we can do however, is hydrolyze the collagen, which means its broken down into much smaller sized pieces ( peptides) by water, making it usable by your body. View abstract. Collagen supplements may help support skin, hair, and joint health. Having, high levels of calcium in your blood is also known as hypercalcemia, and seems to be more predominantly an issue in women., Whether collagen can cause headaches or not is a great question to be asking, especially when trying to decide which supplements are right for you and your body. There are several potential health benefits that collagen supplements offer. Dolan E, Dumas A, Keane KM, Bestetti G, Freitas LHM, Gualano B, Kohrt WM, Kelley GA, Pereira RMR, Sale C, Swinton PA. Sports Med. Guerrero-Toro C, Koroleva K, Ermakova E, Gafurov O, Abushik P, Tavi P, Sitdikova G, Giniatullin R. Int J Mol Sci. By following these tips, you can help ensure safe use of collagen peptides powder and minimize the risk of side effects or health issues. Nutrients. Epub 2020 Nov 12. Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects. "The riskiest side effects of any treatment are usually allergic Side Effects of Copper Peptides Overuse of copper peptides in any form of skincare can be bad, but your best line of defense is just not ingesting them. As a person ages, their joints start to break down. Kouguchi T, Ohmori T, Shimizu M, et al. Can poor sleep impact your weight loss goals? Urinary Metabolomics in Young Soccer Players after Winter Training Season. Learn more about collagen vs. biotin. Kalman DS, Schwartz HI, Pachon J, Sheldon E, Almada AL. View abstract. 2022 Nov 25;14(23):5027. doi: 10.3390/nu14235027. 2019;11(4). A person can also use collagen supplements while following a keto diet plan. Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis. However, it is important to understand what collagen and biotin are and what research is available to support these claims. The researchers theorized that collagen helped stimulate the production of the proteins responsible for muscle growth. Nutrients 2021;13(2):523. Epub 2013 Dec 24. CMJ height recovered quicker with CP than CON at 48 h (P = 0.050; CP 89.96 12.85 vs. CON 78.67 14.41% of baseline values; ES = 0.55). Kumar S, Sugihara F, Suzuki K, Inoue N, Venkateswarathirukumara S. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. View abstract. Recent Advances in Pharmacotherapy for Migraine Prevention: From Pathophysiology to New Drugs. People can consume collagen supplements they purchase from a number of online and local stores, and they can usually find a type that matches their specific dietary needs. Then, we recommend you evaluate the supplement itself along with the dosage you have been using., Not all collagen supplements are created equal and whether collagen can cause headaches may have more to do with the type of collagen you use and its bioavailability to you., When looking at the quality of a collagen supplement, first and foremost check to see if the company can back up their claims., If a company is making any kind of result claims regarding collagens ability to help resolve issues (especially medical issues) then they need to have resources, case studies, and other research to back up these claims., Since the FDA does not regulate collagen supplements as closely as they should, a lot of this is left up to the consumer to identify and sift through. Would you like email updates of new search results? Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Skin Pharmacol Physiol. Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies. Are they suitable for vegans and vegetarians? 2020 Apr;19(4):910-912. doi: 10.1111/jocd.13096. View abstract. Effects of protein supplements on muscle damage, soreness and recovery of muscle function and physical performance: a systematic review. WebAutoimmune diseases (your bodys immune system attacks its own tissue) can damage collagen. IMPORTANT NOTE: Looking for fruits that help to relieve constipation? A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial. 2019;29(5):526-531. doi: 10.1002/brb3.2820. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. Cneo F, Costa-Paiva L, Pinto-Neto AM, Morais SS, Amaya-Farfan J. Bookshelf Because the law does not require cosmetics to be approved by the FDA (Food and Drug Administration), topical skin care products containing collagen peptides are not regulated. Adv Skin Wound Care. The https:// ensures that you are connecting to the One amino acid in particular, glutamic acid official website and that any information you provide is encrypted Hakuta A, Yamaguchi Y, Okawa T, Yamamoto S, Sakai Y, Aihara M. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. In general, the side effects of collagen supplements are mild and can include: Otherwise, in most adults, taking collagen supplements should not pose any significant health risks. Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus. Biosci Biotechnol Biochem. Also, Collagen Peptides supplements have not been found to cause any significant health risks for the majority of consumers. What exactly is the reason collagen can cause a headache? It may help hydrate your skin. As a person ages and collagen production slows, bones can become weaker as the person loses the collagen necessary to keep the bones strong and supported. Maturitas. Saiga-Egusa A, Iwai K, Hayakawa T, Takahata Y, Morimatsu F. Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Osteoarthritis. Results: It is responsible for several biological functions, one of which is to provide structural support in connective tissue, muscle, and skin. Although some experts believe that peptide skin creams or moisturizers are not able to be absorbed fully via the skin, instead recommending oral supplements, some research has nonetheless shown them to have positive effects on skin health. Hydroxyproline, (a key amino acid found in that collagen), can be converted into oxalate and excreted through the kidneys. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. Allergic Reaction. View abstract. WebCollagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. J Cosmet Dermatol. Collagen is a protein that our body already produces, so when taking it in a supplement form, you are replenishing your collagen stores with animal-based collagen., Since it is something that your body already recognizes and needs, the risk is relatively minimal and there are few health concerns about how collagen reacts within your body., Now, this isnt to say that there are no side effects, allergy concerns, or risks involved in taking a collagen supplement., Introducing any new supplement into your diet should be done so with the consultation of a medical professional, especially if you are taking prescription medications, are pregnant, or have any underlying health conditions., Every person taking a supplement may have a different reaction when introducing it into their diet. 2013;77(4):691-6. The role of glutamate and its receptors in migraine. In this study, the women took either a collagen supplement or placebo for 8 weeks. Dizziness. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo. 2015;14(4):291-301. sharing sensitive information, make sure youre on a federal A pilot study for the detection of cyclic prolyl-hydroxyproline (Pro-Hyp) in human blood after ingestion of collagen hydrolysate. Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial. 5. Am J Clin Nutr. Effect of Oral Ingestion of Low-Molecular Collagen Peptides Derived from Skate (Raja Kenojei) Skin on Body Fat in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Possible side effects include: Upset stomach Diarrhea Rashes, or skin reactions Nausea Constipation Heartburn Headache Our team thoroughly researches and evaluates the recommendations we make on our site. 2022 Aug 4;14(8):e27666. Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. Before Most collagen users do not experience any adverse effects when taking a high-quality collagen supplement at the proper dosage., The source of the collagen is also a huge factor in whether or not collagen can cause headaches and other side effects., For instance, many bone broth based collagen supplements are very high in sodium and potassium, not to mention the collagen in that type of supplement is harder to digest.. Int J Sport Nutr Exerc Metab 2021. J Sports Sci Med. This study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. Cardiovascular health: Insomnia linked to greater risk of heart attack. Bruyre O, Zegels B, Leonori L, et al. View abstract. There are some reports that collagen supplements may cause other digestive side effects, such as heartburn and feelings of fullness ( 21 ). J Dermatol Sci. Li X, He Z, Xu J, Su C, Xiao X, Zhang L, Zhang H, Li H. Foods. Conformational Changes in Proteins Caused by High-Pressure Homogenization Promote Nanoparticle Formation in Natural Bone Aqueous Suspension. Potential Cosmetic Active Ingredients Derived from Marine By-Products. National Library of Medicine 2018;17(2):298-304. Biosci Rep. 2018 Dec 14;38(6):BSR20181347. Are they safe, and do they work? The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Pre-Bed Casein Protein Supplementation Does Not Enhance Acute Functional Recovery in Physically Active Males and Females When Exercise is Performed in the Morning. 2020;12(3):618.View abstract. WebCollagen comprises about 60% of cartilage, a very firm tissue that surrounds bones and cushions them from the shock of high-impact movements; so a breakdown in collagen could lead to a loss of cartilage and joint problems. Collagen supplements have the potential to cause both headaches and migraines., According to a few case studies on using collagen to treat osteoarthritis, when participants were using the collagen supplement, they did report a lower pain level in their joints but among the most commonly reported side effects was a headache from time to time.. The https:// ensures that you are connecting to the Federal government websites often end in .gov or .mil. Bagheri Miyab K, Alipoor E, Vaghardoost R, et al. 2008;24(5):1485-96. It is believed that adding more collagen to your diet could potentially cause a deficiency in tryptophan. Would you like email updates of new search results? Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. Insulin is an example of a peptide drug, which is composed of 51 amino acids. 2014;27(3):113-9. doi: 10.1159/000355523. Jung K, Kim SH, Joo KM, et al. This site needs JavaScript to work properly. View abstract. The .gov means its official. 2017;24(13):1332-1349. doi: 10.2174/0929867324666170227115019. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. J Clin Densitom 2021. WebThis study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. doi: 10.1002/14651858.CD009789.pub2. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects. Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Disclaimer. View abstract. Amino Acids 2019;51(4):691-704. The source of the collagen itself should also be a consideration, primarily for those that have a fish or shellfish allergy of any kind. 5. The easiest way to narrow down the absorption rate of a collagen protein is to see if it is hydrolyzed or not., Hydrolyzed or nano hydrolyzed collagen protein supplements, like ProT Gold, are easier to digest because the molecules are smaller and easier for your body to break down.. Something that should be recognized about collagen as a supplement is that it is natural. 2012 Jun;20(3):124-30. Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Oral collagen supplements also increase skin elasticity, hydration, and dermal collagen density. Effects of Collagen Peptides on Recovery Following Eccentric Exercise in Resistance-Trained Males-A Pilot Study. Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. J Cosmet Dermatol. A wide range of dietary supplements is offered to improve skin health. View abstract. 2017 Nov 2;14(6):706-714. doi: 10.1080/19390211.2017.1310781. Jendricke P, Centner C, Zdzieblik D, Gollhofer A, Knig D. Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial. Oral Intake of Enzymatically Decomposed AP Collagen Peptides Improves Skin Moisture and Ceramide and Natural Moisturizing Factor Contents in the Stratum Corneum. These side effects manifest as clinical symptoms best identified by a medical professional. FASEB Experimental Biology 2004 Abstracts, Washington DC, April 17-21, 2004; A90. Bethesda, MD 20894, Web Policies View abstract. View abstract. OTHER NAME(S): Collagen Hydrolysate, Collagen Peptidesi, Collagn, Collagen peptides have most often been used by adults in doses of 2.5-10 grams daily for up to 6 months. One review of the research into collagen supplementation found that using hydrolyzed collagen supplements helps promote joint health and potentially restore some bone density in people with osteoporosis and osteoarthritis. It also plays a role in joint and bone health. Side Effects of Collagen Peptides on the Skin, Anti-Aging Alternatives to Collagen Peptides Supplements, Vitamin C for Acne Scars: Efficacy, How It Works, Before and Afters, Everything You Need To Know About Icon Laser by Cynosure, Vitamin C Serum for Acne: Benefits, How to Choose One, and How to Use It, Everything You Need To Know About PicoSure Laser by Cynosure, Vitamins for Acne: Do They Work? The protein collagen has 3 essential amino acids that decrease constipation, helps with leaky gut syndrome, and even reduces diarrhea. If you have a history of calcium oxalate kidney stones, exercise caution when incorporating collagen peptides by beginning with no more than about 1 tablespoon per day, and always stay well-hydrated. Be sure to choose a collagen peptide product that best suits your needs and goals. Collagen is a type of structural protein in the body. Collagen is a protein that is made up of two fatty acids, lysine and arginine. FOIA The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Int J Sport Nutr Exerc Metab. After those 8 weeks, the women who took the supplement had higher elasticity and moisture levels. View abstract. Am J Med Sci. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Nutrients 2018;10(10). Your body makes collagen naturally, but you can also consume it through collagen supplements Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. The .gov means its official. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. 2022 Jan 28;23(3):1529. doi: 10.3390/ijms23031529. 2005 - 2023 WebMD LLC. In some individuals, this can trigger the formation of kidney stones. Arch Acad Emerg Med 2021;9(1):e50. Collagen Peptides for Hair. 2021;20(3):825-834. There is some evidence to suggest that using collagen supplements may help increase muscle mass. Although collagen peptide supplements are typically considered safe, and there are not many known risks, many supplements are made from potential food allergens such as fish, shellfish and eggs, so its best to avoid these products if you are prone to such allergic reactions. Collagen and biotin may both help promote skin and hair health, but each has different pros and cons. Peptides are also used in Another similar study in the journal Skin Pharmacology and Physiology looked at the effects of collagen supplements on womens skin. J Cosmet Dermatol. eCollection 2022 Aug. Apart from fatigue, this might lead to headaches and feelings of nervousness and irritability. Using a double-blind, independent group's design, 24 recreationally active males consumed either 20 g day-1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. 2016 Feb;116(2):353-62. doi: 10.1007/s00421-015-3290-x. Biosci Biotechnol Biochem. Sci Rep. 2018;8(1):11403. The best vitamins for skin include vitamins C, D, and E. People can get many of these vitamins from their diet or by taking supplements. From arthritis, to skin health, to post surgery healing, a quality collagen supplement can do wonders for your body. When choosing your collagen peptides supplement, be sure its manufacturer hasnt been called out by the FDA. If you have allergies, make sure to purchase supplements that arent made from collagen sources youre sensitive to. A 2016 animal study also found that collagen hydrolysate (also called collagen peptides) reduced fat cell size and weight gain in rats. Maia Campos PMBG, Melo MO, Siqueira Csar FC. Open Neutraceut J. These types of ingredients and additives found in supplements can also be a reason why someone gets a headache versus the collagen molecules themselves., Next, looking at the absorption rate can help you avoid other side effects like bloating or an upset stomach. Can Collagen Cause Diarrhea? 2015;8:29-42. Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. * "It Excessive collagen peptides can lead to a deficit in tryptophan, which causes your serotonin levels to lower. Rahimi MD, Hassani P, Kheirkhah MT, Fadardi JS. 2018;13(4):438-52. Antioxidants for preventing and reducing muscle soreness after exercise. View abstract. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Many people take collagen supplements to add more collagen to their diet. So as you see, collagen can cause headaches and other issues in some people. Epub 2019 Aug 14. Taking collagen supplements may also help support a healthy cardiovascular system. HHS Vulnerability Disclosure, Help Apweiler E, Wallace D, Stansfield S, Allerton DM, Brown MA, Stevenson EJ, Clifford T. Sports (Basel). This site needs JavaScript to work properly. View abstract. Collagen is the protein responsible for skin elasticity. WebYes, collagen does make you poop more! Its always something Type 1: This is one of the most abundant types present in the human body and helps support healthy skin. doi: 10.7759/cureus.27666. For most people, taking collagen should not have any major effects or health consequences. However, some vegan and vegetarian collagen options are available. Nutrients. Lim, S. H., Sun, Y., Thiruvallur Madanagopal, T., Rosa, V., & Kang, L. (2018). Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, et al. Epub 2022 Dec 1. Collagen is a protein that our body already produces, , so when taking it in a supplement form, you are replenishing your collagen stores with animal-based collagen., Beyond the product itself and ingredients, dosage can also impact, how safe it is to use collagen as a daily supplement, Digestive upset such as bloating and nausea, Allergic reactions and general collagen sensitivities, when participants were using the collagen supplement, they did report a lower pain level in their joints but among the most commonly reported side effects was a headache from time to time., However, one common trend we found in our research for this article is that the type of collagen and quality of the supplement itself contributes a lot to the, potential for side effects like headaches, It has been considered that collagen may cause headaches for some users because it can raise your calcium levels. Collagen peptides are popular supplements made from the bones, skin and connective tissue of animals and they have been shown to improve gut 4 Best Ones and Alternatives, Probiotics for Acne: Do They Work, How to Use Them and More, Try a preventative approach. The participants engaged in regular exercise for 12 weeks. Disclaimer. Bone turnover; Collagen; Exercise recovery; Hydrolyzed collagen; Inflammation; Muscle soreness. The takeaway Peptides are amino acids that are the building blocks of certain proteins needed by the skin, like collagen and elastin. These include: Collagen peptide supplements can offer a range of benefits from improved skin health to a reduction in joint pain and stronger hair and nails.