Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. 33. . It cant be more clear than this. Now they turn to Rust. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. . Online. In November, CETF gave the group an additional $500,000 for a phase 3 clinical trial that might show conclusive proof of efficacy. The medical community did nothing (with a few exceptions like Dr. Seftel). Saving the world has been a theme of Kirschs life for years. 90,000 people don't have to die in the next 3 weeks. We asked Steve to tone it down. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. Theres nothing there.). My website. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. He has been a medical philanthropist for more than 20 years. 36m "We found Fauci was the most highly compensated federal employee. [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: One is to reduce the threat of nuclear war. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. It is in a class of drugs known as selective serotonin-reuptake inhibitors (SSRIs), but unlike other SSRIs, fluvoxamine interacts strongly with a protein called the sigma-1 receptor. Fluvoxamine is also an Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. It does not matter how many lives will be saved. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. One Silicon Valley entrepreneur thought he could beat the odds. Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. Doctors who have used fluvoxamine in the US and other countries swear by it. But fear of trying something new prevents any doctor from giving this drug a try. In other cases, stop cold turkey. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. Online Status. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Here are my answers. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. 95% confidence effect size is 75% or more. How covid-19 conspiracy videos keep getting millions of views. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. It has enrolled only 130 people in the first month and is enrolling only 70 per week now. The track management was so impressed, they asked for prescriptions. I've collected fluvoxamine evidence here for convenient access. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. And, according to three members of CETF's scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for . Lack of action. Another CETF grant, though, yielded far more exciting results. And, according to three members of CETFs scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for covid. 1 hr ago. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. The findings, published Wednesday in the New England Journal of Medicine, add to a growing body of scientific evidence pushing back against the use of the antiparasitic drug that has been promoted by some prominent voices on social media. Repurposed drugs are safer and more effective than the current vaccines. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. saying that the per-protocol analysis was arbitrary and other excuses. Compulsive hand washing? The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. Proven in clinical use all over the world. By the beginning of September, he was no longer the companys CEO, replaced by his co-founder, Marten Nelson. Zero. The combined p value of the two studies is <.0001. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. Be warned!. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. No more. Then he hosted a superspreader event. . If you start 5 days after symptoms, all bets are off. Jan 17. But the whole process has gone too slowly for Kirsch. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). The study was also featured on 60 Minutes. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. There is no evidence fluvoxamine is harmful and led to a worse outcome. People who report not tolerating the drug are typically prescribed too high a dose. Fluvoxamine has a 40 year safety track record. I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. It used to be that a Phase 3 study would do it. An MIT Technology Review investigation recently revealed how images of a minor and a tester on the toilet ended up on social media. Get your prescription in advance of getting COVID. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. And that is what has allowed Kirsch, and people like him, to become so influential. This is the gold standard of evidence based medicine. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. sorry about that. Several other trials around the world are in the final stages, too. Do they sell it anywhere? If you cant lay off the java, then try fluoxetine (Prozac). How can we get fluvoxamine? We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. Food/drugs to avoid while on fluvoxamine. , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). The CDC has advised everyone to wear a mask. So it was both obvious and convincing the difference between the groups to the workers and the track management. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. But even that didnt last long. Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. Online Status. Fluvoxamine, COVID, pandemic, . What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Still, in the moment, his question threw me, and I stuttered. . We didnt come up with better mouse technology than Microsoft did. If you have trouble getting a prescription, perhaps you have OCD? None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. So it was both obvious and convincing the difference between the groups to the workers and the track management. The anecdotal data of 100% success rates is further icing on the cake. Its the gold standard of medical evidence. That was a big mistake because the original paper contained text related to earlier studies and the editors chopped it out. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Some speaker, off camera, went on a . Hes a genuinely good guy. Fluvoxamine was reportedly added to just 2 practice guidelines (. . That study was featured on 60 Minutes. Compulsive fiddling with your mask? Last Checked: 03/02/2023. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? Steve Kirsch. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. That is when the phase 2 results were published. You will be wired for 24 hours if you dont heed my advice. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Part of TV News Archive. Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. Quick Summary . I wanted to get the article out before my flight left. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. I must admit that this is an anniversary that snuck The paramedics will think you are on drugs. But a panel of key opinion leaders from the NIH, CDC . has tons of info on fluvoxamine with all the links. It is perhaps the greatest unnecessary loss of life in American history. Read More fluvoxamine The Fluvoxamine FAQ In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. So why would we wait when lives are being lost? When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. I think we did rigorous reviews of proposals for research.. We could have saved a lot of lives. The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). It does not matter how many lives will be saved. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. For decades, coders wrote critical systems in C and C++. Those days are gone. Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . If you cant lay off the java, then try fluoxetine (Prozac). It used to be that a Phase 3 study would do it. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. We should not wait for the Phase 3 RCT. But the confusion provided a fertile breeding ground for skeptics. Fluvoxamine has a 40 year safety track record. As noted before, the repository has a link to the 1 hour serotonin lecture. In severe cases, it takes longer. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. Steve put in $1MM of his own money and . ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. Here is the latest version. See the repository above. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. The evidence is solid. Some countries dont have fluvoxamine so this is the alternative. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead.