This Nebulizer shall be clearly marked to distinguish it from the fit test solution nebulizer. Terms & Conditions Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. 2019;12:91-94. doi: 10.2147/JAA.S189523, Seidman MD, Gurgel RK, Lin SY, et al. Since the delay spray ought to be applied right before having sex, one should always plan his sex ahead.. 2. Avoid alcoholic beverages. Despite the best efforts of parents to keep them safe, young children have a natural - and maddening - tendency to bite, taste or chew the objects around them. It is a compound of a salt with an inert anion such as benzoate or saccharinate. Children are at higher risk for serious (even fatal) side effects, especially breathing problems. Doing so might cause side effects, like gut irritation or sores. Don't believe us? cold feeling or color changes in 1 or both legs or feet. Drug interactions may change how your medications work or increase your risk for serious side effects. *T0T0 Bf (a) Permissible practice. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. JAA. Check the labels on all your medications carefully to make sure you are not taking more than one product that contains guaifenesin. Follow your healthcare provider's advice. After all that time, it's still the best for keeping bugs at bay. 1 0 obj Eye Contact: Contact with the eyes during product use is not expected to result in significant irritation. However, they are not without side effects. You can lessen this effect by using the spray after showering or placing your head over a steamy sink for 5 to 10 minutes. Head Office, Macfarlan Smith, 10 Wheatfield Road, Edinburgh, EH11 2QA, Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as morphine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). 13.3 Didnt work as expected. There is no job too big for Bitter YUCK! Do not feed it to your baby. Some forms of nasal steroid spray are available only when prescribed by your healthcare provider. Bitrex solution molecule size. Pediatrics. Protect from freezing. dry mouth. The penis might feel a little numb in this process. Spray apparatuses, uses of diatomaceous earth, and methods of controlling insect populations is an invention by Roderick William Phillips, Vancouver CANADA. These reactions have been chosen for inclusion due to either their seriousness, frequency of reporting, or causal connection to IMITREX or a combination of these factors. sensitivity screening test, i.e., 10, 20 or 30 squeezes. spray. 25P04RIr Nasal steroid spray use may have a small impact on a childs vertical growth. Only treatment-emergent adverse reactions that occurred at a frequency of 1% or more in the group treated with IMITREX nasal spray 20 mg and that occurred at a frequency greater than the placebo group are included in Table 1. <>stream This causes allergic reactions and inflammation (swelling) in your nose. 22 0 obj Inability to get or maintain an erection. Denatonium, usually available as denatonium benzoate (under trade names such as Denatrol, BITTERANT-b, BITTER+PLUS, Bitrex, Bitrix, and Aversion) and as denatonium saccharide (BITTERANT-s), is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Talk with the doctor about the risks and benefits of this medication.Cough-and-cold products do not cure colds. Long-term use of steroid nasal sprays may impact a child's growth and behavior, so parents and doctors a like should be mindful of these possibilities. Fax: +44 (0)131 337 9813, Home Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. That's especially true if you have just started using nasal steroid sprays for allergies. diarrhea RARE side effects If experienced, these tend to have a Severe expression i bronchospastic lung disease difficulty concentrating If experienced, these tend to have a Less Severe. Nasal steroid sprays are used to treat chronic sinusitis and allergies that affect your breathing, like hay fever. Following product instructions and those provided by a healthcare provider can help you minimize the side effects of steroid nasal sprays. See additional information. You may report side effects to FDA at 1-800-FDA-1088. That chemical, denatonium benzoate, goes by the brand name Bitrex, and its been around since the 1950s. Other Lenzetto side effects are of unknown frequency (frequency can not be estimated from available data) have been reported with Lenzetto from post-marketing surveillance: Alopecia. This patent application was filed with the USPTO on Friday, March 21, 2014 burning or aching pain in your feet or toes while resting. Make sure laboratory personnel and all your doctors know you use this drug. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Side effects of antihistamine nasal sprays might include a bitter taste, drowsiness or feeling tired. 25 0 obj This monograph has been modified to include the generic and brand name in many instances. [1] To name a few common side effects: Bloody nose; Fever; Headache; Muscle Aches; Sore Throat; Troubled Breathing . Sharing it is against the law. Shake the bottle well before using the spray. Tell the doctor right away if you notice any symptoms in your newborn baby such as crying that doesn't stop, slow/shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight. Rinse your eyes with running water for . 46 ($2.18/Fl Oz) Save more with Subscribe & Save. It is used for the treatment of Inappropriate ingestion. Imitrex Nasal Spray Patient Information is supplied by Cerner Multum, Inc. and Imitrex Nasal Spray Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. It is also possible that an overabundance of the IGF-1 in deer antler spray will create side effects similar to excessive amounts of human growth hormone, though no study has backed this theory up. nasal spray. [13], InChI=1S/C21H28N2O.C7H6O2/c1-5-23(6-2,15-19-13-8-7-9-14-19)16-20(24)22-21-17(3)11-10-12-18(21)4;8-7(9)6-4-2-1-3-5-6/h7-14H,5-6,15-16H2,1-4H3;1-5H,(H,8,9), InChI=1/C21H28N2O.C7H6O2/c1-5-23(6-2,15-19-13-8-7-9-14-19)16-20(24)22-21-17(3)11-10-12-18(21)4;8-7(9)6-4-2-1-3-5-6/h7-14H,5-6,15-16H2,1-4H3;1-5H,(H,8,9), [O-]C(=O)c1ccccc1.Cc2cccc(C)c2NC(=O)C[N+](CC)(CC)Cc3ccccc3, Except where otherwise noted, data are given for materials in their, Structure, synthesis, and physical properties. x+r We understand how the rough and tumble of family life works. It's an old-timer, used for more than half a century to ward off mosquitoes and ticks. ANSWER: A recent international study found that women who use cleaning products regularly, particularly those who work as professional cleaners, may have a more rapid decline in lung function over time than women who do not use those products regularly. Sorry, we have no data available. It works by reducing the actions of chemicals in the body that cause inflammation of the skin. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Frank ME, Bouverat BP, MacKinnon BI, Hettinger TP. pressure or heavy feeling in any part of your body. Store at room temperature away from light and moisture. Steroid nasal sprays are not the same as anabolic steroids, drugs that some people use to encourage muscle building. Our Imitrex Nasal Spray (sumatriptan) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. US $5.99Economy Shipping. See also How to Use section for more information about addiction. cracking or tightening of the skin. Keep this medicine in a safe place to prevent theft, misuse, or abuse. Women make up approximately one-half of the US work force. 2. dry skin. Material Safety Data Sheet Denatonium benzoate sc-234525 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION Medical Editor: John P. Cunha, DO, FACOEP. Drink plenty of fluids while you are using this medication unless otherwise directed by your doctor. This is not a complete list of side effects and others may occur. The most common side effects of steroid nasal sprays occur in and around the nostrils, as well as surrounding areas. If you are new to using them, it's important to know that they can lead to side effects. It may slightly increase the risk of birth defects if used during the first two months of pregnancy. The p Burning sensation. J Allergy Clin Immunol Pract. Some general guidelines for treating exposure to paint or paint fumes include: On skin. 13.1 One spray is enough. 16 Surprising Headache Triggers and Tips for Pain Relief. Get medical help right away if you have any very serious side effects, including: seizure. Talk to your doctor about the risks and benefits of this medication. What are the side effects of Biotene Moisturizing Mouth Spray (Saliva Substitutes)? Acute toxicity 1. <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]/ColorSpace<>/Font<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix[1 0 0 1 0 0]/FormType 1/Length 2314/Filter/FlateDecode>>stream Side effects may include any of these symptoms: Dryness, burning, or stinging in the nasal passage. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Beclomethasone nasal spray is used to treat an itchy or runny nose, sneezing, or other symptoms caused by perennial (year-round) or seasonal hay fever (allergic rhinitis). Using a steroid nasal spray the wrong way can cause side effects, so always follow product instructions. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, Treating Opioid Use Disorder With Medications, Constipated? Nose Breather, Local and systemic safety of intranasal corticosteroids, Intranasal fungal (Alternaria) infection related to nasal steroid spray, Overcoming barriers to intranasal corticosteroid use in patients with uncontrolled allergic rhinitis, Growth velocity reduced with once-daily fluticasone furoatenasalsprayin prepubescent children with perennial allergic rhinitis, Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate, Inadequate quality of administration of intranasal corticosteroid sprays, Clinical practice guideline: allergic rhinitis. Studies, however, show mixed results. [12], Nintendo Switch game cards are coated in denatonium benzoate to prevent young children from consuming them. A very serious allergic reaction to this drug is rare. x+r fit test aerosol into the hood. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. If any of these effects last or get worse, tell your doctor or pharmacist promptly. with perch stand. FREE delivery Thu, Feb 16 on . The most dramatic are hallucinations and feeling disconnected from yourself or reality. Simply wash wound and spray on as needed, even on difficult areas such as joints and toes. This combination medication is used to temporarily treat coughing and chest congestion symptoms caused by the common cold, flu, or other breathing illnesses (such as sinusitis, bronchitis). Systemic side effects due to using nasal steroid sprays are relatively rare. The adverse effects varied in severity. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to monitor/avoid these substances in your diet. Sastre J, Mosges R. Local and systemic safety of intranasal corticosteroids. 18) You may feel some tingling sensations don't worry. The more people who support the inclusion of Bitrex in products, the more manufactures will use it. Tell your doctor all medication and supplements you use. If you use a breast pump during this time, throw out any milk you collect. Excessive use of the delay spray can cause temporary sensitivity loss and possibly the loss of an erection for a short period of time. Care Plus Anti-insect Deet Spray 40% - Care Plus DEET is the strongest insect-repellent remedy for the skin. Dry mouth or throat increased nasal congestion Other side effects not listed may also occur in some patients. You may report side effects to Health Canada at 1-866-234-2345. By Daniel More, MD Metaspray Nasal Spray belongs to a group of medicines called topical corticosteroids. This patent application was filed with the USPTO on Friday, March 21, 2014. Methods: A survey was distributed to patients using intranasal steroid sprays at the ENT out-patient clinic at Aberdeen Royal Infirmary over three months. Regardless of the cause, this is one of the most common side effects of ICS. Talk to your doctor if you are using marijuana (cannabis). Last edited on 14 February 2023, at 20:10, "Bitrex(R) Branded Denatonium Benzoate", "The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors", "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction", "Antifreeze and Engine Coolant Being Bittered Nationwide", "Nintendo Switch Cartridges Taste Terrible", https://en.wikipedia.org/w/index.php?title=Denatonium&oldid=1139372578, 163 to 170C (325 to 338F; 436 to 443K), This page was last edited on 14 February 2023, at 20:10. Frequent use of hair spray can lead to difficulty in breathing. vial. Steroid nasal sprays are used to treat inflammation in your sinuses. *T0T0 Bf We understand how the rough and tumble of family life works. Flutiways AZ Nasal Spray - All you have to do is look for the Bitrex logo when you're out shopping. The difference began to show up after just the first month. You may report side effects to FDA at 1-800-FDA-1088. *T0T0 Bf One thimble-full of Bitrex in an Olympic swimming pool is enough to make the water taste bitter. This medication may also cause severe, possibly fatal, breathing problems. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? endobj Check your bottle or ask your pharmacist if your product needs to be shaken. When used for an extended time, this medication may not work as well and may require different dosing. Benzocaine products carry a number of side effects other than methemoglobinemia. But the side-effects can deal a fatal blow to the fun. someone accused me of scratching their car, Five Heritage Sites In Zimbabwe And Their Importance, chief constable lancashire police email address. with perch stand. They help calm your body's response to these irritants, reducing swelling and mucus. Wear a condom, and stay safe. [1] Also, tell your doctor if your condition gets worse, or if you have a headache that doesn't go away, fever, or rash. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Chloasma (golden brown pigment patches, so-called pregnancy spots, Especially in the face), Skin discoloration. 2000;105(2):e23-e23. The incidence of adverse reactions in controlled clinical trials was not affected by gender, weight, or age of the patients; use of prophylactic medications; or presence of aura. Learn about sumatriptan (Imitrex), potential side effects, proper use and dosing, and popular alternatives. Denatonium salts are usually colorless and odorless solids, but are often traded as solutions. A cough or shortness of breath can persist, especially in people with lung disorders. [10], Animals are known to have different sensitivities to the effects of denatonium. Skoner DP, Rachelefsky GS, Meltzer EO, Chervinsky P, Morris RM, Seltzer JM, et al. 15 References. 25P04RIr It also walks you through when to talk to your healthcare provider about them. . Call your doctor for medical advice about side effects. If you have any condition related to your adrenal glands, such as Addison's disease, it is possible for nasal steroid sprays to make them worse. Take the Taste Test and see for yourself. It is also added to many kinds of harmful liquids, including solvents (such as nail polish remover), paints, varnishes, toiletries and other personal care items, special nail polish for preventing nail biting, and various other household products. During pregnancy, this medication is not recommended. View Alerflo Nasal Spray (bottle of 6 gm Nasal Spray) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 1mg.com Imitrex Nasal Spray (Sumatriptan Nasal Spray) , Ear, nose, and throat Disorder/discomfort of. Our special water based formula will not sting or stain. Side effects that are body-wide, such as nausea or infection, can occur but do so less often. dizziness. x+r Insects contact its active ingredient while crawling/moving on the sprayed surfaces, ensuring fast and long lasting effect. Common side effects of Imitrex Nasal Spray include: Serious side effects of Imitrex Nasal Spray include: Tell your doctor right away if you have any serious side effects of Imitrex Nasal Spray including: Seek medical care or call 911 at once if you have the following serious side effects: This document does not contain all possible side effects and others may occur. 2012;22(1):1-12.. Chang GH, Wang WH. Contact Us Consult your doctor or pharmacist about using this medication safely. What should I know regarding pregnancy, nursing and administering Btrex Oral to children or the elderly? [1], The name "denatonium" reflects the substance's primary use as a denaturant and its chemical nature as a cation, hence the New Latin suffix -onium. Keep all medications away from children and pets. Sharing safety tips to help you protect your children from accidental poisoning. The unique formulation is packaged in an atomizer bottle, allowing owners to spray the product on things their dogs seem to be drawn to lick or chew. I was having chest pain this morning, when the paramedics came she gave me the gtn spray but before that she gave me an orange flavoured tablet to chew, does anyone know what this was, I didn't get any side effects from the spray and wondered if it was the tablet I took before it. If you experience these symptoms, talk to your healthcare provider. Do not breastfeed within 12 hours after using Imitrex Nasal Spray. In some people, this change happens faster and more completely than usual, which increases the risk of very serious side effects. It was attributed to the medication itself after ruling out all other factors. Please contact your doctor or pharmacist. People who use nasal steroid sprays over long periods of time may need to be checked periodically for any damage or complications. 1Pc Parrot weight s Plaqueoff 180g - Reduce Plaque and Tartar - Pets & Animals / Dogs, Puppies PlaqueOff Powder is a pet dental product for both cats and dogs. Alerflo Nasal Spray is used in the treatment of Sneezing and runny nose due to allergies,Severe allergic reactions,Skin conditions with inflammation & itching. 6. The fluid will help loosen the mucus in your lungs. SKIN CONTACT: Prolonged skin contact may cause mild irritation. 18) You may feel some tingling sensations dont worry. Take your next dose at the regular time. "It's the most effective ingredient . <>stream <>stream We understand that parents get harassed, tired, and up to their eyes. endstream See details. Bitrex. It wont make you sick or ill, it just tastes so bitter that you will want to spit it out fast. 16 0 obj Based on test data and/or inform ation on t he components, this m aterial may produce the following health effects: Inhalation: Respiratory Tract Irritation: Signs/symptoms may include cough, sneezing, nasal discharge, headache, hoarseness, and nose Care Plus Anti-insect Deet Spray 40% - Care Plus DEET is the strongest insect-repellent remedy for the skin. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Most accidental poisonings happen when products are in use. Steroid nasal spray use can sometimes lead to body-wide side effects, though these are less common. Sneezing. However, be sure to see a healthcare provider if you think you may be experiencing any. Scale range: 1G- 10000G. There has been some concern about hyperactivity, irritability, or behavioral problems in children who regularly use nasal steroid sprays. EYE CONTACT: May cause mild eye irritation. Common side effects of Imitrex Nasal Spray include: mild headache (not a migraine), pressure or heavy feeling in any part of your body, Rashes. by tahitian vanilla candle sand and fog. Signs. This medication may interfere with certain laboratory tests (such as urine 5-HIAA levels, urine VMA levels, amylase/lipase levels), possibly causing false test results. One designation in particular, SD-40B, indicates that ethanol has been denatured using denatonium benzoate. fatigue (low energy) feeling unusually warm or cold. endobj In Canada - Call your doctor for medical advice about side effects. It is a steroid (cortisone-like medicine) that works by preventing the inflammation that occurs with allergic reactions. Get medical help right away if you notice any of the following: slow/shallow breathing, severe drowsiness/difficulty waking up, confusion. Your name may need to be listed on a pregnancy registry. Valtoco side effects Get emergency medical help if you have signs of an allergic reaction to Valtoco: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Extreme temperatures may affect viscosity but will not affect product performance. From cleaning products to cosmetics, garden pesticides to anti-freeze, firelighters to air fresheners. Proper technique is very important. Overcoming barriers to intranasal corticosteroid use in patients with uncontrolled allergic rhinitis. Side effects are common, but these may be related to the method of application rather than the medication itself. endstream These include breaks in the skin (ulceration)or small holes (perforation) in the septum, found between your nostrils. Your healthcare provider may prescribe one for you. A substance thats put into household, garden and automotive products to ensure that if a child or animal ever tried to swallow it, they would spit it straight out before they could be poisoned. Inadequate quality of administration of intranasal corticosteroid sprays. 13.2 Will buy more bottles. 25P04RIr If you notice any other effects, check with your healthcare professional. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Do not double the dose to catch up. 16) There could be other uncomfortable side-effects. May 20, 2021; kate taylor jersey channel islands; someone accused me of scratching their car . x+r Daniel More, MD, is a board-certified allergist and clinical immunologist with a background in internal medicine. Chang GH, Wang WH. Remember the name. Sumatriptan is a white to off-white powder that is readily soluble in water and in saline.Each IMITREX Nasal Spray contains 5 or 20 mg of sumatriptan in a 100-L unit dose aqueous buffered solution containing monobasic potassium phosphate NF, anhydrous dibasic sodium phosphate USP, sulfuric acid NF, sodium . In fact, The Guinness World Records lists Bitrex as the most bitter substance in the world.. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Fluticasone nasal spray is a corticosteroid (or steroid). endstream Though it helps many people, this product has a risk for abuse and may sometimes cause addiction. Heres how we can all play our part in keeping our homes and our children safe. chest pain, dizziness, or nausea while you're having sex (if these side effects do not get better when you stop and rest) an erection that does not go away and lasts more than 4 hours sudden. In the US - Call your doctor for medical advice about side effects. If you have bleeding and irritation of your nasal passages, it can increase your risk of more serious complications. Bitrex is the brand name of the bitterest substance in the world. SPRAY APPARATUSES, USES OF DIATOMACEOUS EARTH, AND METHODS OF CONTROLLING INSECT POPULATIONS is an invention by Roderick William Phillips, Vancouver CANADA. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. They are thought to be safe and effective for treating allergy symptoms in both adults and children. back pain. [1], Denatonium also discourages consumption of poisonous alcohols such as methanol and additives such as ethylene glycol. *T0T0 Bf This is not a complete list of possible side effects. Integr Pharm Res Pract. test conductor shall spray the Threshold Check Solution into the enclosure. In rare cases, eating a Tide Pod on purpose (or accidentally) could lead to death due to breathing problems or other complications, Dr. Lynch says. It can be obtained by the quaternization of lidocaine, a popular anesthetic, with benzyl halides. Intranasal fungal (Alternaria) infection related to nasal steroid spray. Itll pass. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Ask your doctor or pharmacist for more details. Liquid forms of this medication may contain sugar, alcohol, or aspartame. Host a Taste Test and help us spread the word about Bitrex. doi: 10.1542/peds.105.2.e23, Rollema C, Roon EN van, Vries TW de. Read our, Causes and Risk Factors of Sinus Infection. Otherwise, call a poison control center right away. Flutiways AZ Nasal Spray , - Flutiways AZ Nasal Spray Side Effects in Hindi . spray and the 0.062% concentration of Hot Sauce did not differ (P > 0.05) from the control (tap water), a 6.2% concentration of Hot Sauce (100 times 16) There could be other uncomfortable side-effects. Using nasal sprays for a prolonged period of time can lead to bleeding from the nose and even headaches. Despite the best efforts of parents to keep them safe, young children have a natural and maddening tendency to bite, taste or chew the objects around them. Blistering, flaking skin. Dont believe us? [2], Dilutions of as little as 10ppm are unbearably bitter to most humans. Irritability. WebMD does not provide medical advice, diagnosis or treatment. 4. Scale for weighing pet parrots and birds, and small animals. You can lessen this effect by using the spray after showering or placing your head over a steamy sink for 5 to 10 minutes. They received either beclomethasone dipropionate (BDP) spray for their allergy symptoms or a fake treatment (placebo). required as was necessary to elicit a response in the threshold. including hypertensive crises, on rare occasions in patients with or without a history of hypertension. This document does not contain all possible drug interactions. fever, sore throat, chills, cough, and other signs of infection whistling sound from the nose hives rash itching swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs hoarseness difficulty breathing or swallowing wheezing feeling faint severe or frequent nosebleeds Do not start, stop, or change the dosage of any medicines without your doctor's approval.